A Case Report about Early Major Postoperative Ossifications of the Shoulder

What to Learn from this Article?

Surgical resection of posttraumatic heterotopic ossifications of the shoulder must be practiced only if they impact the joints function.

Case Report | Volume 6 | Issue 4 | JOCR September-October 2016 | Page 80-83 | Maurice Kouame, Moctar Traore, Armand Yepie, Michel Anoumou DOI: 10.13107/jocr.2250-0685.582

Authors: Maurice Kouame[1], Moctar Traore[1], Armand Yepie[1], Michel Anoumou[1]

[1]Department of Orthopaedics, Treichville Teaching Hospital, Abidjan, Ivory Coast, 2Department of Bone and Joints, University Félix Houphouet-
Boigny, Cocody, Abidjan, Ivory Coast.
Address of Correspondence:
Dr. Maurice Kouame,
Department of Bone and Joints, University Félix Houphouet-Boigny, P.O. Box 440, Cocody, Abidjan, Ivory Coast. Tel.: 225-07938533, Fax: ???.
E-mail: khamaurice@yahhoo.fr


Introduction: Ossifications after osteosynthesis of the proximal humerus are poorly described. We report a case of major and early ossifications after synthesis of a fracture dislocation of the shoulder.
Case presentation: A 57 year-old man, right-handed, bipolar schizophrenic, presented after a fall, a fracture of the head and metaphysis of the humerus from the anterior notch of posterior dislocation of the right humerus. An osteosynthesis was performed after reduction on the tenth post-traumatic day. The postoperative period was complicated because of early ossifications and painless stiffness of the shoulder.
Conclusion: The importance of local trauma, the long consultation period, the operative difficulties and the heparin therapy are factors that could have favored the occurrence of ossifications. Preventive treatment could have prevented them or limited their extent.
Keywords: shoulder, humerus, surgery, heterotopic ossification.

Ossifications were described for the first time in the shoulder by Smith in 1835 [1] and are rather the consequence of arthroplasty [2]. Several predisposing factors have been described [3]. They are rare after synthesis of the proximal humerus and compromise little the functional prognosis of the shoulder [4].
Our objective is to report the observation of major and early ossifications after osteosynthesis of a fracture dislocation of the humeral head and make a review of the literature.

Case presentation
Mr. K.F. a 57 year-old man, right-handed, bipolar schizophrenic, was the victim of a mechanical fall from standing height. On admission, neurological examination was normal. A painful strain evoked a broken left wrist. The right shoulder was swollen, painful and non functional. Radiography objectified anterior marginal fracture of the distal radius and fracture of the proximal humerus with suspected posterior dislocation associated (Fig. 1). The computed tomography scan confirmed the diagnosis of complex proximal humeral fracture associated with posterior dislocation of the humeral head. This was a fracture in four fragments of Neer associated with posterior dislocation or fracture of the head and metaphysis of the femur from the anterior notch of posterior dislocation according to Duparc [5]. An anteroinferior marginal fracture of the glenoid (Fig. 2a and 2b) was associated.fig-1-2
An osteosynthesis of the wrist bone was carried out in emergency. Ten days later, the synthesis of the humeral fracture was performed by extended deltopectoral approach. The minor tubercle held up, the long biceps broken is resected and undergoes tenodesis in its groove. The humeral cap united to the metaphyseal diaphyseal posteromedial beak is reduced then screwed in compression. We fix again the fragment of the major tubercle fractured by osteosuture and the minor tubercle is screwed into the cephalic notch. The synthesis is carried out by a small fragment LCP plate. The incision is closed over a suction drain. The limb is held by a derotation device. Analgesic treatment, preventive heparin therapy were prescribed. The immediate postoperative course was uneventful and the control radiography satisfactory (Fig. 3a, 3b). Healing was obtained in the normal time. Rehabilitation started on the fourth day by assisted passive and active mobilization, joint and muscle maintenance. The derotation system is kept between sessions for five weeks.
The discharge from the hospital was carried out 28 days after shoulder surgery. Three weeks later, the radiography showed ossifications with grade 3 glenoid starting point according to Kjærsgaard-Andersen [6] (Fig. 4a). Successive checks confirmed ossifications (Fig. 4b and 4c). Six months later, the shoulder was stiff and painless with active anterior elevation to 70 °, active abduction to 45 °, external rotation (ER1) nil and thumb to the right buttock in internal rotation. The hand-mouth was possible and the hand-head was limit. Glenoid humeral ossifications were identical (Fig. 4d).fig-3-4

Ossifications after osteosynthesis of the proximal humerus are reported in a proportion of 0 to 10% [4, 7]. Males would be predisposed to them [3, 8] without any preferred age unlike the hip where the sixties are more exposed [6]. Our patient is a fifty-seven-year man.
Their occurrence mechanism is still unclear [2, 3, 9]. Hereditary and acquired factors, trauma and certain treatments such as heparin therapy might predispose to their formation [1, 3, 4, 7, 9-12]. The operative difficulties and the intervention beyond ten days due to the transformation of the hematoma around the fracture may increase the risk [1, 12]. We still ignore the possible role of immobilization and rehabilitation in the process of periarticular ossification after surgery [1]. Some of these factors exist in our patient. The importance of local trauma is certain. The intervention was carried out within ten days and was quite difficult with enlargement of the approach. These factors coupled with the heparin therapy, could justify ossifications. Moreover, the neurological origin cannot be discussed because there is no notion of head trauma or coma. We have no knowledge of a study incriminating schizophrenia in ectopic osteogenesis.
The therapeutic indications in proximal humerus fractures are a matter of debate. What is important is to find the indication that adapts to the patient’s needs and to obtain the support of the latter for the treatment chosen [7]. The lesion in our patient is a particular form because of low risk of necrosis according to Favard et al [13]. Treatment is conservative.
Our indication of osteosynthesis, seems perfectly licit. The correct reconstruction of the fracture confirms our choice. In addition, ossifications are more frequent in prosthetic shoulder with rates ranging up to 45% [2] than in synthesis. Pre and postoperative external radiotherapy and anti-inflammatory drugs (NSAIDs) are two preventive methods of postoperative ossifications. For the NSAIDs, indomethacin molecule is usually used in three daily doses of 25 mg from the first operative day to six to twelve weeks. It was used for the first time in 1975 by Dahl in higher doses [14]. Its prescription is limited by its gastrointestinal complications and contra-indication in renally impaired subjects. For radiotherapy, protocols are quite varied. But in recent studies [15], two patterns seem to be accepted. This is on the one hand the single preoperative irradiation of seven to eight grays, four hours prior to surgery, and on the other hand, the single irradiation at the same dose until the fourth postoperative day. Their effectiveness is essentially identical [14, 15]. The major complication of radiotherapy is the occurrence of cancer that single doses seem to minimize.
Radiation therapy and NSAIDs work by the same biochemical and cytological mechanisms. They prevent the formation of osteoblastic cells by inhibiting the differentiation of mesenchymal cells, thereby preventing the formation of ectopic bone. With very different side effects, external radiotherapy and NSAIDs are equally effective [3, 8, 10, 14, 15]. The choice of one or other of the methods depends on the therapist and takes into account the patient’s organism and the therapeutic cost. On this latter criterion, indomethacin is recognized more accessible. In our clinical case report, indomethacin was the most accessible means that we should have prescribed in prevention of the postoperative period.
Ossifications appear between four and twelve weeks, and their formation is not gradual [2]. The biological process of their formation starts as soon as the sixteenth posttraumatic hour, peaking between thirty-six and forty-eight hours [8, 10]. Their diagnosis is accessible on the radiography between three and six weeks. In our patient, they formed very early, as they were already visible on radiographies three weeks postoperatively. They remained stable for six months, confirming the results mentioned above.
Ossifications are rarely painful and little influence joint function [2, 12]. Sanders et al [9] advocate their surgical resection and arthrolysis coupled to a preventive treatment of recurrences when they are aggressive either through pain, or by mechanical action on the joint. For Plausinis et al [12], surgical treatment is licit, provided that the patient has objective limitations of joint mobility. Our patient presents a fairly limited articular mobility, but he seems to adapt to it from the point of view of the gestures of everyday life. He does not complain of any pain. We therefore believe that there is no need to intervene again immediately.

Heterotopic ossifications following osteosynthesis of the proximal humerus are poorly reported. It is important to know the contributing factors and seek them faced with a complex fracture of the shoulder to institute a prophylactic treatment. Their surgical resection is discussed if they are aggressive and painful and is subject to a morphological assessment and a careful surgical planning to maturity.

Clinical message

Even if heterotopic ossifications following osteosynthesis of the proximal humerus are poorly reported, precautions to avoid them must be taken, when the contributing factors exist. The diagnosis of those factors is imperative in front of joints trauma. When diagnosed, the surgical resection of heterotopic ossifications needs a careful surgical planning and must respect functional needs of the patient.

1- Erggelet C, Eggensperger G, Steinwachs M, Lahm A, Reichelt A. Postoperative ossifications of the shoulder. Incidence and clinical impact. Arch Orthop Trauma Surg 1999 ;119 :168-170.
2- Sperling JW, Cofield RH and Rowland CM. Heterotopic ossification after total shoulder arthroplasty. J Arthroplasty 2000;15(2):179-182.
3- Kinapfel H, Koller M, Wüst A, Sprey C, Merte H, Engenhart-Cabillic R, Griss B. Prevention of heterotopic bone after total hip arthroplasty : a prospective randomized study comparing postoperative radiation therapy with indomethacin medication. Arch Orthop Trauma Surg 1999;119:296-302.
4- Connor PM, Flatow EL. Complications of internal fixation of proximal humeral fractures. Orthop 2002;25(11):1255-57.
5- Vandenbusssche E, Huten D. Fractures de l’extrémité supérieure de l’humérus. Encycl Méd Chir (Elsevier, Paris). Appareil locomoteur 14-038-A-10;2000:20p.
6- Kjaersgaard-Andersen P, Frich LK, Sojbierg JO, Sneppen O. Heterotopic bone formation following total shoulder arthroplasty. J Arthroplasty 1989;4:99.
7- Dimakopoulos P, Kassimatis G and Panagopoulos A. Transosseous suture fixation of proximal humeral fractures. J Bone Joint Surg Am 2007; 89:1700-1709.
8- Seegenschmiedt MH, Martus P, Goldmann AR, Wölfel R, Keilholz L, Sauer R. Preoperative versus postoperative radiotherapy for prevention of heterotopic ossification (HO): First results of a randomized trial in high-risk patients. Int J Radiation Oncology Biol Phys 1994;30(1):63-73.
9- Sanders BS, Wilcox III RB, Higgins LD. Heterotopic ossifiction of the deltoid muscle after arthrotopic rotator cuff repair. Am J Orthop 2010;39(7):E67-E71.
10- Moore KD, Goss K, Anglen JO. Indomethacin versus radiation therapy against heterotopic ossification in acetabular fractures. A randomized prospective study. J Bone Joint Surg Br 1998;80-B(2):259-263.
11- Chao ST, Lee SY, Borden LS, joyce MJ, Krebs VE, Suh JH. External beam radiation helps prevent heteroptopic bone formation in patients with a history of heterotopic ossification. J Arthroplasty 2006;21(5):731-735.
12- Plausinis D, Kwon YW and Zukermann JD. Complications of humeral head replacement for proximal humeral fractures. J Bone Surg Am 2005;87:204-213.
13- Favard L, Berhouet J, Bacle G. Traitement chirurgical des fractures de l’extrémité supérieure de l’humérus de l’adulte. Encycl Méd Chir (Elsevier, Paris). Techniques chirurgicales – Orthopédie-Traumatologie 2010;44-290:13p.
14- Zouhair A, Ozsabin M, Mouhsine E, Leyvraz PF, Mirimanoff RO, Coucke PA. Radiothérapie externe ou anti-inflammatoire non stéroïdien pour la prévention des ossifications hétérotopiques après prothèse totale de hanche. Schweiz Med Wochenschr 1999;129:370-6.
15- Nasr E, Nehme R, Ghanem I, Azoury F, Nehme Nasr D, Dagher F. Rôle de la radiothérapie dans l’ossification hétérotopique. Cancer Radiother 2009;13:42-46.

How to Cite This Article: Kouame M, Traore M, Yepie A, Anoumou M. A Case Report about Early Major Postoperative Ossifications of the Shoulder. Journal of Orthopaedic Case Reports 2016 Sep-Oct;6(4): 80-83. Available from: http://www.jocr.co.in/wp/2016/10/10/2250-0685-582-fulltext/


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